Association between obesity and severe treatment outcomes in patients with COVID-19

Vol. 12 – Number 47 – 2021 INTERDISCIPLINARY NOTEBOOK Systematic review Page 138-142 Association between obesity and severe treatment outcomes in patients with COVID-19 Giordana Gregório Fritsch1 Michael Wesley Schmidt2 Antônio Carlos Gargioni Filho3 Hussein Nasser Fares4 ABSTRACT The worldwide population is facing a double burden of epidemic, the COVID-19and obesity. This is even more alarming as obesity increases the COVID-19 severity. However, the relationship between obesity and COVID-19 severity is more complex than a simple association with BMI. In particular, obesity has been associated with low death rates in patients with acute respiratory distress syndrome, a fatal comorbidity to COVID-19, possibly due to the obesity paradox. Also, visceral adiposity could be a major risk factor for COVID- -19severity, due to its immune activation component, release of ACE2 and involvement in the cytokine storm, It is also known to correlate with metabolic disorders, low-grade inflammation and higher mortality rates. Descriptors: COVID-19, SARS-CoV-2, obesity. 1 Specialist in Implant Dentistry – SL Mandic, Medical Student – UNIC. 2 Specialist in Oral and Maxillofacial Surgery and Traumatology – FaSerra, Medical Student – UNIC. 3 Dr. in Dentistry – UNITAU, Medical Student – UNIC. 4 Graduating in Medicine – Uninove, Residency in Orthopedics – Inst. DOI: 10.24077/2021;1247138142