Clinical implications of L-PRF use in dental oral surgeries

Vol. 12 – Number 46 – 2021 IMPLANT DENTISTRY NOTEBOOK Systematic review Page 81-87 Clinical implications of L-PRF use in dental oral surgeries Ana Luíza Gonçalves Girundi1 Francisco Mauro da Silva Girundi2 Rodrigo Porto Guimarães3 Vinícius Rodrigues Santos4 Wander José da Silva5 Abstract The autologous blood concentrate L-PRF is responsible for the healing response in surgical procedures. However, studies results are inconclusive. Therefore, the aim of this article was to collect existing literature’s evidence concerning the clinical implications of L-PRF use in oral surgeries such as maxillary sinus lift, alveolus filling after dental extractions, and dental implants. Pubmed database was assessed and randomized clinical trials between 2006 and 2019 considering the clinical implications of L-PRF use in oral surgeries were included. A hundred and seventy articles were identified and fifteen were selected by eligibility. Although some studies had diverged, the great majority evidenced improved healing process, osseointegration and reduced post-operation pain because of L-PRF use, what was attributed to the morphological and biological characteristics of the fibrin membrane that has a three-dimensional matrix due to lack of anticoagulant during its formation, and stores growth factors, leukocytes, cytokines, and bone cells. In addition, this fibrin matrix attracts undifferentiated stem cells that will become osteoblasts. In conclusion, the greater cicatricial response, less postoperative discomfort for the patient, increased bone formation and implant-bone contact (BIC), and reduced osseointegration period are benefits associated with the L-PRF membrane use, that make L-PRF to be considered a good choice in the field of tissue regeneration. Descriptors: Platelet rich fibrin, bone regeneration, healing. 1 Spe. in Prosthesis and Implant. 2 Spe. prosthesis, Esp. and Me. in Implant, Dr. in Prosthesis. 3 Spe. in Implant, Me. in Implant. 4 Spe. in Prosthesis, Me. in Prosthesis. 5 MSc. And Dr. in Prosthesis, Prof. – FOP-UNICAMP. DOI: 10.24077/2021;1246-8187