Orofacial harmonization: advantages and differences between Calcium Hydroxyapatite and Poly-L-lactic acid

Vol. 3 – Number 11 – 2022 Review article Page 62-72 Orofacial harmonization: advantages and differences between Calcium Hydroxyapatite and Poly-L-lactic acid Cintia Helena Pereira Silveira¹ Aline Carolina Favoretto Cordeiro2 Daniel Witchmichen Krukoski3 Elisa Capa Bataglin1 Dilgênio Tiburski Júnior4 Giulia Pereira Periolo5 ABSTRACT Biostimulators are substances that stimulate collagen production when injected into the skin, they can be used to restore volume in the long term and reduce sagging. Calcium Hydroxyapatite – CaHA is present in teeth and bones, it is a biocompatible product with high degree of safety due to the low inflammatory response verified by the smooth surface and regular size of the microparticles, presenting the advantage of being normally produced in the human body. Besides this, it provides volume replacement and collagen biostimulation, it is a biodegradable material, and it is naturally reabsorbed by the host’s metabolic processes, being able to immediately restore volume, in addition to filling and correcting specific creases and cavities. It is ideal for use in all areas of the face except the glabella, periorbital area and lips. Poly-L-lactic Acid (PLLA) is a semipermanent filler with results of approximately four years and it is also biodegradable. The general objective of this study is to analyze the advantages and differences between the CaHA better known by the trademark Diamond and Radiesse and the PLLA known by the trademark Elleva and Sculptra. For this we used qualitative research whose main method is the bibliographic study with literature review in books and articles on the subject. Data collection was carried out through websites (Google Academic and SciELO) with the following descriptors: Biostimulators, Calcium Hydroxyapatite, Poly-L-lactic and Collagen, having as inclusion criteria scientific articles that have analyzed the differences and similarities between CaHA and PLLA, besides the main products used in order to facilitate their choice in facial harmonization treatments. The exclusion criteria included articles repeated on both sites and articles with publication period prior to 2009. The results indicated that the Elleva product from the Rennova brand, which has PLLA as an active ingredient, presented more benefits in relation to its competitor brand the Sculptra. Descriptors: Biostimulators, collagen, Poly-L-lactic, Calcium Hydroxyapatite. 1 CD, Specialist in Orofacial Harmonization – FAIPE and NULAB. 2 Spec. in Aesthetic Biomedicine, M. in Pharmacy, Professor of the Specialization Course in Orofacial Harmonization – FAIPE AND NULAB. 3 Esp. and M. in Biochemical Sciences, Prof. of the Specialization Course in Orofacial Harmonization – FAIPE AND NULAB. 4 Coordinator of the Specialization Course in Orofacial Harmonization – FAIPE E NULAB. 5 Odontology student – UNIVALI. DOI: 10.24077/2022;3113133